Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates

Brain Res. 1997 May 23;757(2):285-90. doi: 10.1016/s0006-8993(97)00337-5.


The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus functions as a circadian pacemaker. This study used multimicroelectrode plates to measure extracellular action potential activity simultaneously from multiple sites within the cultured mouse SCN. Neurons within the isolated mouse SCN expressed a circadian rhythm in spontaneous firing rate for weeks in culture.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Cells, Cultured
  • Circadian Rhythm*
  • Electrophysiology
  • Extracellular Space / physiology
  • Mice
  • Mice, Inbred C57BL
  • Microelectrodes
  • Neurons / physiology
  • Suprachiasmatic Nucleus / cytology
  • Suprachiasmatic Nucleus / physiology*