Risk factors for capillary leakage syndrome after bone marrow transplantation

Ann Hematol. 1997 May;74(5):221-4. doi: 10.1007/s002770050288.


Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related, unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients after BMT. CLS was defined as unexplained weight gain of > 3% within 24 h and nonresponsiveness to furosemide. CLS occurred in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p = 0.0017) for hematopoietic disorders (n = 54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p = 0.001) for solid tumors (n = 42). Hematopoietic growth factors and cyclosporin A were no significant risk factors on their own. We conclude that unrelated BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for CLS.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Bone Marrow Transplantation / adverse effects*
  • Capillary Leak Syndrome / epidemiology
  • Capillary Leak Syndrome / etiology*
  • Capillary Leak Syndrome / prevention & control
  • Graft vs Host Disease / prevention & control
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
  • Humans
  • Incidence
  • Prospective Studies
  • Risk Factors
  • Transplantation Conditioning
  • Transplantation, Homologous / immunology


  • Granulocyte Colony-Stimulating Factor
  • Granulocyte-Macrophage Colony-Stimulating Factor