Liquid chromatographic analysis of cocaine and benzoylecgonine in plasma of traditional coca chewers from Bolivia during exercise

J Ethnopharmacol. 1997 May;56(3):173-8. doi: 10.1016/s0378-8741(97)00029-9.


The purpose of the present study was to determine the amount of cocaine and benzoylecgonine in the plasma of Aymara Indians from the Bolivian Andes after traditional chewing of coca leaves during exercise performance. The determination was carried out by high performance liquid chromatography after solid-liquid extraction. The results showed that such use of coca leaves is well correlated with pharmacologically active concentration of cocaine in plasma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bolivia
  • Chromatography, High Pressure Liquid
  • Coca*
  • Cocaine / analogs & derivatives*
  • Cocaine / blood*
  • Exercise
  • Humans
  • Indians, South American
  • Male
  • Middle Aged
  • Plants, Medicinal*


  • benzoylecgonine
  • Cocaine