Higher cerebral dysfunction in a case with atypical multiple sclerosis with concentric lesions

Psychiatry Clin Neurosci. 1996 Feb;50(1):41-4. doi: 10.1111/j.1440-1819.1996.tb01661.x.


A patient with atypical multiple sclerosis (MS) with clear concentric structure was studied using high field magnetic resonance imaging (MRI). This case was considered to be Baló's concentric sclerosis. Magnetic resonance imaging showed diffuse multiple concentric demyelinating lesions in the bilateral centrum semiovales, which finally regressed with the necrotic lesions remaining when the patient was discharged. During his clinical course, he showed some higher cerebral dysfunctions, such as memory disturbance, constructual apraxia and acalculia. He was treated with glycerin, prednisone and rehabilitation; all of which were effective in his recovery. Over a 4 month period, the patient recovered clinically, but some intellectual impairment remained.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology*
  • Cognition Disorders / diagnosis
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / pathology*
  • Neuropsychological Tests
  • Reflex, Babinski