Hepatitis C virus infection and related liver disease in children of mothers with antibodies to the virus

J Pediatr. 1997 Jun;130(6):990-3. doi: 10.1016/s0022-3476(97)70289-0.


Objective: To evaluate the clinical, biochemical, and virologic features associated with hepatitis C virus (HCV) infection acquired early in life from mothers with antibodies to HCV (anti-HCV).

Study design: Multicenter prospective-retrospective study in Italian children.

Patients: Two groups of children were investigated. Group 1 included 14 infants, born to mothers with anti-HCV but without human immunodeficiency virus infection, who became seropositive for HCV RNA during the first year of life and were thus considered infected. Group 2 included 16 children with chronic hepatitis C, aged 1 1/2 to 14 years, whose mothers were the unique potential source of infection. Both groups were followed for 12 to 48 months.

Methods: Alanine transaminase (ALT), anti-HCV, and HCV RNA were investigated by the polymerase chain reaction on entry to the study and during follow-up.

Results: All children in group 1 had anti-HCV throughout follow-up, and all had ALT abnormalities, ranging from 1.5 to 10.5 times the normal value during the first 12 months. During further follow-up, 5 of 10 children had HCV RNA with abnormal ALT values, 3 had a return to normal of the ALT values but continued to have viremia, and 2 eventually had normal ALT values and clearance of HCV RNA. Of the 16 children in group 2, all were free of symptoms and 62% had only slight ALT elevations; 7 who underwent liver biopsy had histologic features of minimal or moderate hepatitis.

Conclusions: HCV infection acquired early in life from mothers with anti-HCV is usually associated with biochemical features of liver damage during the first 12 months of life. Progression to chronicity seems to occur in the majority of cases, although HCV-associated liver disease is likely to be mild throughout infancy and childhood.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study

MeSH terms

  • Alanine Transaminase / blood
  • Antibodies / isolation & purification*
  • Chronic Disease
  • Female
  • HIV Seropositivity / complications
  • Hepatitis / etiology*
  • Hepatitis C / complications*
  • Humans
  • Immunoglobulin M
  • Infant
  • Male
  • Polymerase Chain Reaction
  • Prospective Studies
  • RNA, Viral
  • Retrospective Studies


  • Antibodies
  • Immunoglobulin M
  • RNA, Viral
  • Alanine Transaminase