Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein

Mech Dev. 1997 May;63(2):173-86. doi: 10.1016/s0925-4773(97)00039-7.


Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membrane protein of a new type, which does not display similarities with previously characterized integral membrane proteins. Stra6, which exhibits a specific pattern of expression during development and in the adult, is strongly expressed at the level of blood-organ barriers. Interestingly, in testis Sertoli cells, Stra6 has a spermatogenic cycle-dependent expression which is lost in testes of RAR alpha null mutants where Stra6 is expressed in all tubules. We suggest that the Stra6 protein may be a component of an as yet unidentified transport machinery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carcinoma, Embryonal / genetics
  • Choroid Plexus / metabolism
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Male
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Pigment Epithelium of Eye / metabolism
  • Placenta / metabolism
  • Receptors, Retinoic Acid / deficiency
  • Retinoic Acid Receptor alpha
  • Retinoid X Receptors
  • Sertoli Cells / metabolism
  • Time Factors
  • Tissue Distribution
  • Transcription Factors / deficiency
  • Tretinoin / pharmacology
  • Tumor Cells, Cultured
  • Yolk Sac / metabolism


  • Membrane Proteins
  • Rara protein, mouse
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Retinoid X Receptors
  • Stra6 protein, mouse
  • Transcription Factors
  • Tretinoin

Associated data

  • GENBANK/AF062476