Xwnt-2b is a novel axis-inducing Xenopus Wnt, which is expressed in embryonic brain

Mech Dev. 1997 May;63(2):199-209. doi: 10.1016/s0925-4773(97)00041-5.


Xwnt-2b is a novel member of the Wnt gene family and is 73-74% similar to human and mouse Wnt-2 proteins. Starting from stage 15, Xwnt-2b transcripts are localized to a non-contiguous stripe in the anterior neural plate of the Xenopus embryo. In the tailbud, Xwnt-2b is expressed along the dorsoanterior side of the prosencephalon-mesencephalon boundary. At the tadpole stages, the brain-specific expression fades, but the total amount of Xwnt-2b mRNA does not decline due to activation of its expression in non-brain areas. Microinjection of Xwnt-2b mRNA into a ventral blastomere of 4-8-cell embryos results in the formation of complete secondary body axes. These results suggest that Xwnt-2b is a member of the axis-inducing Wnts and that it is involved in brain development and in later organogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Body Patterning / genetics*
  • Brain / embryology
  • Brain / metabolism*
  • Gene Expression Regulation, Developmental*
  • Glycoproteins / biosynthesis
  • Glycoproteins / genetics*
  • Homeodomain Proteins / metabolism
  • Humans
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism
  • Rats
  • Sequence Homology, Amino Acid
  • Wnt2 Protein
  • Xenopus / genetics*
  • Xenopus Proteins*
  • Zebrafish


  • Glycoproteins
  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • WNT2B protein, Xenopus
  • Wnt2 Protein
  • Xenopus Proteins
  • engrailed 2 protein

Associated data

  • GENBANK/U66288