T cell clonal anergy

Curr Opin Immunol. 1997 Jun;9(3):351-7. doi: 10.1016/s0952-7915(97)80081-7.

Abstract

Recent experiments have elucidated two molecular mechanisms that may account for the failure of anergic T cell clones to initiate IL-2 gene transcription following TCR stimulation. First, a block has been identified in the ERK and JNK mitogen-activated protein kinase pathways; the block results from a failure to activate p21ras. It leads to reduced induction of c-Fos and JunB proteins and to a failure to form and phosphorylate the activator protein (AP)-1 heterodimers required for IL-2 gene transcriptional activation. Second, repressor molecules (Nil-2-a and a molecule related to AP-1) have been characterized that dominantly inhibit IL-2 gene transcription.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Interleukin-2 / genetics
  • Interleukin-2 / immunology
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology*
  • T-Lymphocyte Subsets / immunology*
  • Transcription, Genetic

Substances

  • Interleukin-2
  • Receptors, Antigen, T-Cell