The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation

Eur J Pharmacol. 1997 Jun 5;328(1):61-4. doi: 10.1016/s0014-2999(97)83028-2.

Abstract

These studies in anaesthetised rats showed, using intravital microscopy, that the novel anti-migraine agent, rizatriptan, significantly reduced electrically stimulated dural vasodilation but had no effect on increases in dural vessel diameter produced by exogenous substance P or calcitonin gene-related peptide (CGRP). Rizatriptan also significantly inhibited dural plasma protein extravasation produced by high intensity electrical stimulation of the trigeminal ganglion. We suggest that rizatriptan inhibits the release of sensory neuropeptides from perivascular trigeminal nerves to prevent neurogenic vasodilation and extravasation in the dura mater. These prejunctional inhibitory effects may be involved in the anti-migraine action of rizatriptan.

MeSH terms

  • Analysis of Variance
  • Animals
  • Blood Proteins / drug effects
  • Blood Proteins / metabolism*
  • Calcitonin Gene-Related Peptide / metabolism
  • Calcitonin Gene-Related Peptide / pharmacology
  • Disease Models, Animal
  • Dura Mater / blood supply
  • Dura Mater / drug effects*
  • Dura Mater / metabolism
  • Electric Stimulation
  • Injections, Intravenous
  • Lethal Dose 50
  • Male
  • Meningeal Arteries / drug effects
  • Meningeal Arteries / physiology
  • Migraine Disorders / drug therapy
  • Neuromuscular Junction / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin Receptor Agonists / administration & dosage
  • Serotonin Receptor Agonists / pharmacology*
  • Serotonin Receptor Agonists / therapeutic use
  • Substance P / metabolism
  • Substance P / pharmacology
  • Triazoles / administration & dosage
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use
  • Trigeminal Nuclei / drug effects
  • Trigeminal Nuclei / physiology
  • Tryptamines
  • Vasodilation / drug effects*

Substances

  • Blood Proteins
  • Serotonin Receptor Agonists
  • Triazoles
  • Tryptamines
  • Substance P
  • rizatriptan
  • Calcitonin Gene-Related Peptide