Progress in protein structure prediction

Curr Opin Struct Biol. 1997 Jun;7(3):377-87. doi: 10.1016/s0959-440x(97)80055-3.


If protein structure prediction methods are to make any impact on the impending onerous task of analyzing the large numbers of unknown protein sequences generated by the ongoing genome-sequencing projects, it is vital that they make the difficult transition from computational 'gedankenexperiments' to practical software tools. This has already happened in the field of comparative modelling and is currently happening in the threading field. Unfortunately, there is little evidence of this transition happening in the field of ab initio tertiary-structure prediction.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Computer Simulation
  • Forecasting
  • Models, Molecular*
  • Protein Conformation*
  • Protein Folding
  • Protein Structure, Tertiary
  • Proteins / chemistry*


  • Proteins