Predicting coiled-coil regions in proteins

Curr Opin Struct Biol. 1997 Jun;7(3):388-93. doi: 10.1016/s0959-440x(97)80056-5.


The past several years have seen significant advances in our ability to recognize coiled coils from protein sequences and model their structures. New methods include a detection program based on pairwise residue correlations, a program that distinguishes two-stranded from three-stranded coiled coils and a routine for modelling the coordinates of the core residues in coiled coils. Several widely noted predictions, among them those for heterotrimeric G proteins and for cartilage oligomeric matrix protein, have been confirmed by crystal structures, and several new predictions have been made, including a model for the still hypothetical right-handed coiled coil.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Computer Simulation
  • Crystallography, X-Ray
  • GTP-Binding Proteins / chemistry
  • Models, Molecular*
  • Protein Conformation
  • Proteins / chemistry*
  • Software


  • Proteins
  • GTP-Binding Proteins