Three-dimensional domain duplication, swapping and stealing

Curr Opin Struct Biol. 1997 Jun;7(3):416-21. doi: 10.1016/s0959-440x(97)80060-7.


Examination of multidomain and/or multimeric protein structures can reveal evolutionary paths to a more complex 3D organization. Over the past few years, proteins have been shown to evolve while preserving mutual domain organization and interfaces. The recent advances in understanding domain reorganization and mobility highlight the versatility and efficiency of protein structural evolution.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Evolution, Molecular
  • Leucine Zippers
  • Models, Molecular*
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / genetics
  • Proteins / metabolism*


  • Proteins