PDZ domains: targeting signalling molecules to sub-membranous sites

Bioessays. 1997 Jun;19(6):469-79. doi: 10.1002/bies.950190606.

Abstract

PDZ (also called DHR or GLGF) domains are found in diverse membrane-associated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin-associated proteins, collectively known as syntrophins. Many PDZ domain-containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C-terminal polypeptides of a subset of NMDA receptor subunits and/or with Shaker-type K+ channels. Other PDZ domains have been shown to bind similar ligands of other transmembrane receptors. Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand-binding and the structural bases for sequence conservation among diverse PDZ domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Humans
  • Ligands
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Nucleoside-Phosphate Kinase / genetics*
  • Nucleoside-Phosphate Kinase / metabolism
  • Sequence Alignment
  • Sequence Analysis
  • Signal Transduction*

Substances

  • Carrier Proteins
  • Ligands
  • Membrane Proteins
  • Nucleoside-Phosphate Kinase

Associated data

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  • GENBANK/D26309
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