A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13

Genomics. 1997 Jun 15;42(3):405-12. doi: 10.1006/geno.1997.4773.


A transcription map of a 1200-kb region encompassing the MEN1 locus was constructed by direct cDNA selection and mapping ESTs. A total of 29 genes were mapped. Ten transcripts were identified by cDNA selection of a focused 300-kb genomic region telomeric to the MEN1 consensus region. Since many of the sequences cloned by cDNA selection also identified ESTs from the region, 19 additional RH-mapped ESTs were mapped to the entire contig region by PCR amplification of genomic clones. Nine known genes, 2 putative human homologues to mouse genes, and 18 novel transcripts map to the region. Transcripts that map to the MEN1 interval PYGM-D11S449 include SGC35223, IB1256, AA147620, ZFM1, FAU, and CAPN1. The latter 3 known genes have already been excluded as candidate MEN1 genes. The 2 putative human homologues of mouse genes Ltbp2 and Spa-1 may be candidate tumor suppressor genes, but they map telomeric to D11S449. Although both of these genes map outside the MEN1 consensus region they may play a role in sporadic endocrine tumors independent of the MEN1 gene or in other tumors, such as breast cancer, that have loss of heterozygosity within this region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Blotting, Northern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Multiple Endocrine Neoplasia Type 1 / genetics*
  • Neoplasm Proteins / genetics*
  • Proto-Oncogene Proteins*
  • Sequence Analysis, DNA
  • Transcription, Genetic


  • MEN1 protein, human
  • Neoplasm Proteins
  • Proto-Oncogene Proteins

Associated data

  • GENBANK/U80781
  • GENBANK/U80782
  • GENBANK/U80783
  • GENBANK/U80784
  • GENBANK/U80785
  • GENBANK/U80786
  • GENBANK/U80963
  • GENBANK/U80964
  • GENBANK/U80965