Abstract
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Capillary Permeability
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Contrast Media / administration & dosage*
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Drug Carriers
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Drug Combinations
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Drug Delivery Systems / methods*
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Gadolinium DTPA
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Image Enhancement / methods*
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Liposomes
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Macromolecular Substances
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Magnetic Resonance Imaging / methods*
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Male
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Meglumine / administration & dosage*
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Microscopy, Electron, Scanning Transmission
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Organometallic Compounds / administration & dosage*
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Pentetic Acid / administration & dosage
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Pentetic Acid / analogs & derivatives*
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Rabbits
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Random Allocation
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Ultrasonic Therapy / methods*
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Ultrasonography, Doppler, Pulsed / methods*
Substances
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Contrast Media
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Drug Carriers
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Drug Combinations
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Liposomes
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Macromolecular Substances
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Organometallic Compounds
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Meglumine
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Pentetic Acid
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Gadolinium DTPA