Granulosa cell tumor of the ovary associated with antecedent tamoxifen use

Obstet Gynecol. 1994 Oct;84(4 Pt 2):717-9.


Background: Increased attention has been focused recently on the estrogenic effects of tamoxifen. Review of the literature reveals an association between tamoxifen use and gynecologic tumors.

Case: A 52-year-old postmenopausal woman was treated with tamoxifen for stage II estrogen receptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels increase markedly after 6 months of tamoxifen use. After an additional 17 months of elevated serum transaminases, the patient was found to have a stage Ic granulosa cell tumor of the ovary.

Conclusion: Patients with tamoxifen-induced liver dysfunction may be at increased risk for granulosa cell tumors because of alterations in tamoxifen metabolism.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Agents, Hormonal / adverse effects*
  • Breast Neoplasms / drug therapy*
  • Female
  • Granulosa Cell Tumor / chemically induced*
  • Humans
  • Middle Aged
  • Neoplasms, Second Primary / chemically induced*
  • Ovarian Neoplasms / chemically induced*
  • Tamoxifen / adverse effects*


  • Antineoplastic Agents, Hormonal
  • Tamoxifen