[Correlation of ultrasound biomicroscopy with histological findings in diagnosis of giant cell arteritis]

Klin Monbl Augenheilkd. 1997 Jan;210(1):48-52. doi: 10.1055/s-2008-1035013.
[Article in German]


Background: A biopsy of the temporal arteries is still the appropriate method to prove the diagnosis of giant cell arteritis. We evaluated the potential use of high-resolution ultrasound-biomicroscopy in the diagnosis of giant cell arteritis.

Patients and methods: In a prospective study we examined 16 patients (8 women and 8 men) with a mean age of 71 years with the clinical suspicion of a giant cell arteritis. Additionally to the clinical examination the temporal arteries were imaged in all patients using the ultrasound-biomicroscopy (Zeiss-Humphrey Instruments). The results were correlated to the histopathologic changes of the temporal arteries excised bilaterally at the same location.

Results: Histopathological evaluation revealed a granulomatous arteritis in 4 out of 16 examined patients. The temporal arteries of these patients also showed characteristic changes using ultrasound biomicroscopy like middle-reflective shadowing of the arterial lumen and a condensation and enlargement of the muscularis media. Ultrasound-biomicroscopy allowed a precise evaluation of the temporal arteries due to a high-resolution sonographic image. The morphological differentiation between a normal and an affected artery was possible. A positive correlation between histopathological and clinical findings was seen in all patients.

Conclusion: In this preliminary study the ultrasound-biomicroscopy seemed to be an appropriate non-invasive tool for the morphological imaging and evaluation of temporal arteries.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biopsy
  • Equipment Design
  • Female
  • Giant Cell Arteritis / diagnosis*
  • Giant Cell Arteritis / pathology
  • Humans
  • Male
  • Microscopy / instrumentation*
  • Middle Aged
  • Prospective Studies
  • Sensitivity and Specificity
  • Temporal Arteries / pathology*
  • Ultrasonography / instrumentation*