Recombinant follicle-stimulating hormone (follitropin beta, Puregon) yields higher pregnancy rates in in vitro fertilization than urinary gonadotropins

Fertil Steril. 1997 Jul;68(1):138-42. doi: 10.1016/s0015-0282(97)81490-2.


Objective: To assess ongoing pregnancy rates (PRs) in IVF after treatment with recombinant FSH (follitropin beta, Puregon; NV Organon, Oss, The Netherlands) as compared with urinary gonadotropins.

Design: A combined analysis of three prospective, multicenter, randomized, comparative trials.

Setting: Twenty-five IVF centers in 13 countries.

Patient(s): Six hundred ninety-seven infertile women receiving recombinant FSH and 463 women receiving hMG or urinary FSH and undergoing one cycle of controlled ovarian hyperstimulation and IVF-ET.

Intervention(s): A center-based and study-based analysis weighing the treatment differences in individual centers and studies, respectively.

Main outcome measures(s): Pregnancy rate at least 12 weeks after ET per started cycle.

Results(s): In the center-based analysis, the ongoing PR was 22.9% for recombinant FSH and 17.9% for urinary gonadotropins. The 5.0% treatment difference (95% confidence interval [CI], 0.2% to 9.7%) was significant. When the results of the cryoprogram were included, the treatment difference increased to 6.4% (95% CI, 1.4% to 11.3%). Also in the study-based analysis, significantly higher PRs were seen after follitropin beta treatment.

Conclusion(s): Follitropin beta (Puregon) used for controlled ovarian hyperstimulation in IVF yields significantly higher PRs compared with urinary gonadotropins.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Embryo Transfer
  • Female
  • Fertilization in Vitro / methods*
  • Follicle Stimulating Hormone / administration & dosage
  • Follicle Stimulating Hormone / standards*
  • Follicle Stimulating Hormone / urine
  • Follicle Stimulating Hormone, beta Subunit
  • Humans
  • Menotropins / administration & dosage
  • Pregnancy Rate*
  • Prospective Studies
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / standards


  • Follicle Stimulating Hormone, beta Subunit
  • Recombinant Proteins
  • Menotropins
  • Follicle Stimulating Hormone