Clonal chromosome aberrations in three of five sporadic angiomyolipomas of the kidney

Cancer Genet Cytogenet. 1997 Jul 1;96(1):42-5. doi: 10.1016/s0165-4608(96)00267-1.


Clonal chromosomal changes were detected in three of five sporadic angiomyolipomas of the kidney irrespective of a solitary or multifocal appearance of this benign tumor type. No specific chromosomal changes have been identified. Including the cytogenetic data of the four renal angiomyolipomas reported in the literature, trisomy 7 as the single clonal chromosomal abnormality was detected in two angiomyolipomas. Because trisomy 7 has been reported in both neoplastic and nonneoplastic kidney cells, it may be assumed that trisomy 7 is already physiologically resident in renal cells but undergoes positive selection in this tumor type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Angiomyolipoma / genetics*
  • Angiomyolipoma / pathology
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Kidney Neoplasms / genetics*
  • Kidney Neoplasms / pathology
  • Male
  • Middle Aged