Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: demonstration of principle

Am J Primatol. 1997;42(3):215-24. doi: 10.1002/(SICI)1098-2345(1997)42:3<215::AID-AJP4>3.0.CO;2-#.


We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMRGlcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Animals
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Deoxyglucose / administration & dosage
  • Deoxyglucose / analogs & derivatives*
  • Deoxyglucose / pharmacokinetics
  • Female
  • Fluorine Radioisotopes* / administration & dosage
  • Fluorine Radioisotopes* / pharmacokinetics
  • Fluorodeoxyglucose F18
  • Glucose / metabolism*
  • Injections, Intravenous
  • Macaca mulatta
  • Male
  • Time Factors
  • Tissue Distribution
  • Tomography, Emission-Computed / methods
  • Tomography, Emission-Computed / veterinary*


  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Glucose