Carcinogenesis: a balance between beta-catenin and APC

Curr Biol. 1997 Jul 1;7(7):R443-6. doi: 10.1016/s0960-9822(06)00214-4.

Abstract

A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / genetics
  • Adenomatous Polyposis Coli Protein
  • Animals
  • Armadillo Domain Proteins
  • Cytoskeletal Proteins / genetics*
  • DNA-Binding Proteins / genetics*
  • Drosophila Proteins*
  • Gene Expression Regulation, Neoplastic*
  • Genes, Tumor Suppressor*
  • Humans
  • Insect Proteins / genetics*
  • Lymphoid Enhancer-Binding Factor 1
  • Trans-Activators*
  • Transcription Factors / genetics*
  • beta Catenin

Substances

  • Adenomatous Polyposis Coli Protein
  • Armadillo Domain Proteins
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Insect Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Trans-Activators
  • Transcription Factors
  • beta Catenin