Airborne (1-->3)-beta-D-glucan and airway disease in a day-care center before and after renovation

Arch Environ Health. 1997 Jul-Aug;52(4):281-5. doi: 10.1080/00039899709602199.


Changes in symptoms and airway responsiveness among persons who worked in a day-care center that had microbial growth problems were assessed before and after renovation. Before and after the building renovation, the investigators used the Limulus assay with (1-->3)-beta-D-glucan-specific lysate to measure airborne levels of (1-->3)-beta-D-glucan, a cell-wall component of molds. Airway responsiveness and subjective symptoms were measured among 14 female employees with a methacholine test and a standardized questionnaire. After the renovation, (1-->3)-beta-D-glucan-glucan levels decreased from 11.4 to 1.4 ng/m3. The number of persons who had increased airway responsiveness decreased after the renovation. Two employees developed a classical allergy to cat and pollen during the observation period. Although the study included only a few subjects and was based on only one day-care center, the data suggest that (1-->3)-beta-D-glucan may be related to airways inflammation caused by indoor air pollution.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollutants / analysis*
  • Air Pollution, Indoor / adverse effects
  • Air Pollution, Indoor / analysis
  • Bronchitis / diagnosis
  • Bronchitis / etiology*
  • Child
  • Child Day Care Centers*
  • Facility Design and Construction
  • Female
  • Glucans / analysis*
  • Humans
  • Middle Aged
  • Occupational Diseases / diagnosis
  • Occupational Diseases / etiology*
  • Surveys and Questionnaires


  • Air Pollutants
  • Glucans