Cytoarchitecture of the entorhinal cortex in schizophrenia

Am J Psychiatry. 1997 Jul;154(7):1010-2. doi: 10.1176/ajp.154.7.1010.


Objective: The purpose of this study was to determine whether schizophrenia is associated with abnormalities in neuronal migration in the entorhinal cortex.

Method: Nissl-stained sections through three cytoarchitectonic subdivisions of the entorhinal cortex were examined in postmortem brain specimens from 10 schizophrenic subjects and 10 matched normal comparison subjects.

Results: No qualitative differences in cytoarchitecture were observed between the schizophrenic and comparison subjects.

Conclusions: These findings do not replicate previous reports of cytoarchitectural disturbances in the entorhinal cortex of schizophrenic subjects and thus fail to support the hypothesis of abnormal neuronal migration in schizophrenia.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Entorhinal Cortex / abnormalities
  • Entorhinal Cortex / anatomy & histology*
  • Humans
  • Neural Tube Defects / pathology
  • Schizophrenia / diagnosis*
  • Schizophrenia / pathology