Molecular aspects of intracellular sterol esterification: the acyl coenzyme A: cholesterol acyltransferase reaction

Curr Opin Lipidol. 1997 Jun;8(3):167-73. doi: 10.1097/00041433-199706000-00007.

Abstract

The conversion of cholesterol to an esterified storage form by the enzyme acyl-coenzyme A: cholesterol acyltransferase, is a critical component of sterol and membrane homeostasis and represents a significant step in atherogenesis. The isolation in 1993 of the first molecular probe of acyl-coenzyme A: cholesterol acyltransferase provided a key to understanding this reaction and its regulation. The sequence is apparently ubiquitous in eukaryotes, often with multiple sequence homologs within an organism. Presented here is a review of the known molecular events that lead to intracellular sterol esterification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / enzymology
  • Arteriosclerosis / physiopathology
  • Arteriosclerosis / prevention & control
  • Esters
  • Homeostasis
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Multigene Family
  • Phylogeny
  • Saccharomyces cerevisiae / enzymology
  • Sterol O-Acyltransferase / genetics
  • Sterol O-Acyltransferase / metabolism*
  • Sterols / metabolism*

Substances

  • Esters
  • Sterols
  • Sterol O-Acyltransferase