The recent increase in emerging diseases can be attributed to a number of factors, all of which relate to some form of alteration in the way etiologic agents move around. Some of these factors responsible for altered agent trafficking include actual transport to a susceptible population or new species, environmental disruption that facilitates exchange of microbes, and a husbandry change that promotes new ways for microbes to move around. Given the exponential growth of the human population and all the attendant implications, including the mobility of this population, the ecological disruption that is accompanying the overall increase, and the necessity of exploring new agricultural technologies to feed a burgeoning population, it is a certainty that altered agent trafficking will not only continue but will undoubtedly increase. Veterinarians should be aware of the role they will be expected to play in this field.