Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents

Med Res Rev. 1997 Jul;17(4):367-425. doi: 10.1002/(sici)1098-1128(199707)17:4<367::aid-med3>3.0.co;2-u.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Camptothecin / chemistry
  • Camptothecin / pharmacology
  • Chemistry, Pharmaceutical
  • Computer-Aided Design
  • Drug Design*
  • Humans
  • Lethal Dose 50
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Structure-Activity Relationship
  • Topoisomerase I Inhibitors*
  • Topoisomerase II Inhibitors*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors
  • Camptothecin