Bacterial Resistance to Aminoglycoside Antibiotics

Trends Microbiol. 1997 Jun;5(6):234-40. doi: 10.1016/S0966-842X(97)01033-0.

Abstract

The aminoglycoside antibiotics are broad-spectrum antibacterial compounds that are used extensively for the treatment of many bacterial infections. In view of the current concerns over the global rise in antibiotic-resistant microorganisms, there has been renewed interest in the mechanisms of resistance to the aminoglycosides, including the superfamily of aminoglycoside-modifying enzymes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism
  • Amino Acid Sequence
  • Aminoglycosides
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Carbohydrate Sequence
  • Drug Resistance, Microbial / genetics
  • Molecular Sequence Data
  • Molecular Structure
  • Mycobacterium
  • Nucleotidyltransferases / genetics
  • Nucleotidyltransferases / metabolism
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Phosphotransferases / genetics
  • Phosphotransferases / metabolism
  • Streptomyces / genetics

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Acetyltransferases
  • Phosphotransferases
  • Phosphotransferases (Alcohol Group Acceptor)
  • streptomycin 6-kinase
  • Nucleotidyltransferases
  • aminoglycoside 6-adenylyltransferase