Germline TCR-A restriction of immunoglobulin E responses to allergen

Immunogenetics. 1997;46(3):226-30. doi: 10.1007/s002510050266.


Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1(*)2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1(*)1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1(*)2 and HLA-DRB1(*)1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / immunology*
  • Animals
  • Antibody Formation
  • Female
  • HLA-D Antigens / genetics
  • Humans
  • Immunoglobulin E / immunology*
  • Male
  • Mites / immunology
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*


  • Allergens
  • HLA-D Antigens
  • Receptors, Antigen, T-Cell, alpha-beta
  • Immunoglobulin E