Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair

Nat Med. 1997 Jul;3(7):721-2. doi: 10.1038/nm0797-721.
No abstract available

Publication types

  • News

MeSH terms

  • Animals
  • BRCA1 Protein / genetics*
  • BRCA1 Protein / physiology
  • BRCA2 Protein
  • Breast Neoplasms / genetics*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins / genetics
  • DNA Repair*
  • DNA-Binding Proteins / genetics
  • Female
  • Humans
  • Mice
  • Mutation
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / physiology
  • Rad51 Recombinase
  • Signal Transduction
  • Transcription Factors / genetics*
  • Transcription Factors / physiology
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / physiology

Substances

  • BRCA1 Protein
  • BRCA2 Protein
  • CDKN1A protein, human
  • Cdkn1a protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • RAD51 protein, human
  • Rad51 Recombinase
  • Rad51 protein, mouse