Abstract
Patients with chronic facial pain including those with facial arthromyalgia (TMJ dysfunction syndrome) were investigated for evidence of abnormal systemic and intra-articular free radical activity. Chronic facial pain patients showed significantly raised serum 2,3-dihydroxybenzoic acid after an oral dose of 1.2 g of aspirin which indicates increased systemic free radical activity. This was reflected in the TMJ aspirates of the facial arthromyalgia patients which contained thiobarbituric acid-reactive substance (TBA-RS) which is also a product of free radical activity. The synovial aspirates also contained high levels of the hyperalgesic eicosanoid 15-HETE. However, there was no difference between the painful and symptom-free joints, which suggested that in part the clinical features are probably determined by asymmetrical masticatory function or as yet unknown algesic factors such as local cytokine production.
MeSH terms
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Administration, Oral
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Aspirin / administration & dosage
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Aspirin / pharmacokinetics
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Case-Control Studies
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Chronic Disease
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Cytokines / metabolism
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Dinoprostone / analysis
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Facial Pain / etiology*
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Facial Pain / metabolism
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Female
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Free Radicals / metabolism
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Free Radicals / pharmacology
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Gentisates*
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Humans
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Hydroxybenzoates / blood
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Hydroxyeicosatetraenoic Acids / analysis
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Iron Chelating Agents / analysis
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Leukotriene B4 / analysis
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Male
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Mastication
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Middle Aged
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Reactive Oxygen Species / metabolism
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Reactive Oxygen Species / physiology*
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Synovial Fluid / chemistry
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Temporomandibular Joint / metabolism
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Temporomandibular Joint Dysfunction Syndrome / etiology
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Temporomandibular Joint Dysfunction Syndrome / metabolism
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Thiobarbituric Acid Reactive Substances / analysis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Free Radicals
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Gentisates
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Hydroxybenzoates
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Hydroxyeicosatetraenoic Acids
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Iron Chelating Agents
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Reactive Oxygen Species
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Thiobarbituric Acid Reactive Substances
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Leukotriene B4
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2,3-dihydroxybenzoic acid
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15-hydroxy-5,8,11,13-eicosatetraenoic acid
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Dinoprostone
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Aspirin
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2,5-dihydroxybenzoic acid