Abstract
AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role for these receptors in developmental processes. In the function of the hematopoietic and nervous systems and in tumorigenesis.
MeSH terms
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Animals
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Axl Receptor Tyrosine Kinase
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Cell Division / physiology*
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Humans
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Intercellular Signaling Peptides and Proteins*
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Oncogene Proteins / chemistry
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Oncogene Proteins / physiology*
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Protein-Tyrosine Kinases / chemistry
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Protein-Tyrosine Kinases / physiology
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Proteins / physiology
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Proto-Oncogene Proteins / chemistry
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Proto-Oncogene Proteins / physiology
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Receptor Protein-Tyrosine Kinases / chemistry
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Receptor Protein-Tyrosine Kinases / physiology*
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c-Mer Tyrosine Kinase
Substances
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Intercellular Signaling Peptides and Proteins
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Oncogene Proteins
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Proteins
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Proto-Oncogene Proteins
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growth arrest-specific protein 6
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MERTK protein, human
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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TYRO3 protein, human
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c-Mer Tyrosine Kinase
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Axl Receptor Tyrosine Kinase
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AXL protein, human