New insights into the control of cell growth; the role of the AxI family

Pathology. 1997 May;29(2):131-5. doi: 10.1080/00313029700169744.

Abstract

AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role for these receptors in developmental processes. In the function of the hematopoietic and nervous systems and in tumorigenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Axl Receptor Tyrosine Kinase
  • Cell Division / physiology*
  • Humans
  • Intercellular Signaling Peptides and Proteins*
  • Oncogene Proteins / chemistry
  • Oncogene Proteins / physiology*
  • Protein-Tyrosine Kinases / chemistry
  • Protein-Tyrosine Kinases / physiology
  • Proteins / physiology
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / physiology
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor Protein-Tyrosine Kinases / physiology*
  • c-Mer Tyrosine Kinase

Substances

  • Intercellular Signaling Peptides and Proteins
  • Oncogene Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • growth arrest-specific protein 6
  • MERTK protein, human
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • TYRO3 protein, human
  • c-Mer Tyrosine Kinase
  • Axl Receptor Tyrosine Kinase
  • AXL protein, human