Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives

J Nat Prod. 1997 May;60(5):519-24. doi: 10.1021/np970165u.


The antifungal activity of several xanthones isolated from the fruit hulls of Garcinia mangostana and some derivatives of mangostin against three phytopathogenic fungi, Fusarium oxysporum vasinfectum, Alternaria tenuis, and Dreschlera oryzae, has been evaluated. The natural xanthones showed good inhibitory activity against the three fungi. Substitution in the A and C rings has been shown to modify the bioactivities of the compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Alternaria / drug effects
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Fusarium / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Mitosporic Fungi / drug effects
  • Plants, Medicinal / chemistry*
  • Xanthines / isolation & purification*
  • Xanthines / pharmacology


  • Antifungal Agents
  • Xanthines