Abstract
Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after i.p. administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the effect was comparable to that of 1,1-dimethylbiguanide (metformin).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology
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Blood Glucose / metabolism
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Body Weight / drug effects
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Cresols / isolation & purification*
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Cresols / pharmacology
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / drug therapy
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Female
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Hypoglycemic Agents / isolation & purification*
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Hypoglycemic Agents / pharmacology
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Male
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Metformin / pharmacology
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plants, Medicinal / chemistry*
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Rats
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology
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Wood
Substances
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Benzofurans
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Blood Glucose
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Cresols
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Glucosides
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Hypoglycemic Agents
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Phenols
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Stilbenes
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pterostilbene
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pterosupin
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marsupsin
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Metformin