Coassembly of TRP and TRPL produces a distinct store-operated conductance

Cell. 1997 Jun 27;89(7):1155-64. doi: 10.1016/s0092-8674(00)80302-5.


The Drosophila retinal-specific protein, TRP (transient receptor potential), is the founding member of a family of store-operated channels (SOCs) conserved from C. elegans to humans. In vitro studies indicate that TRP is a SOC, but that the related retinal protein, TRPL, is constitutively active. In the current work, we report that coexpression of TRP and TRPL leads to a store-operated, outwardly rectifying current distinct from that owing to either TRP or TRPL alone. TRP and TRPL interact directly, indicating that the TRP-TRPL-dependent current is mediated by heteromultimeric association between the two subunits. We propose that the light-activated current in photoreceptor cells is produced by a combination of TRP homo- and TRP-TRPL heteromultimers.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium Channels / chemistry
  • Calcium Channels / isolation & purification
  • Calcium Channels / metabolism*
  • Calmodulin-Binding Proteins / chemistry
  • Calmodulin-Binding Proteins / isolation & purification
  • Calmodulin-Binding Proteins / metabolism*
  • Cell Membrane / chemistry
  • Cells, Cultured
  • Drosophila / chemistry
  • Drosophila / physiology
  • Drosophila Proteins*
  • Electric Conductivity
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / isolation & purification
  • Membrane Proteins / metabolism*
  • Patch-Clamp Techniques
  • Photoreceptor Cells, Invertebrate / physiology
  • Precipitin Tests
  • Protein Binding / physiology
  • Protein Structure, Tertiary
  • TRPC Cation Channels
  • Transient Receptor Potential Channels
  • Yeasts / chemistry
  • Yeasts / physiology


  • Calcium Channels
  • Calmodulin-Binding Proteins
  • Drosophila Proteins
  • Membrane Proteins
  • TRPC Cation Channels
  • Transient Receptor Potential Channels
  • transient receptor potential cation channel, subfamily C, member 1
  • trpl protein, Drosophila

Associated data

  • GENBANK/Y13758