Modulation of hormone-dependent transcriptional activity of the glucocorticoid receptor by the tumor suppressor p53

Cancer Lett. 1997 Jun 24;116(2):191-6. doi: 10.1016/s0304-3835(97)00186-9.

Abstract

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor which regulates growth, development and metabolic functions. To test the hypothesis that the pleiotropic effect of the GR could be mediated by other transcription factors/oncogenes, the present study assessed its interaction with the tumor suppressor p53. p53 is a transcription factor which is involved in cell cycle regulation and apoptosis. We found that the wild-type p53 physically interacted with the GR and repressed the glucocorticoid-dependent transcriptional activity. In contrast, mutant p53 had no or a lesser effect depending on the type of p53 mutant. These findings raised the possibility that p53 may play an important role in modulating the activities of glucocorticoids in cells.

MeSH terms

  • Cell Cycle
  • Glucocorticoids / physiology*
  • Humans
  • Receptors, Glucocorticoid / physiology*
  • Transcription Factors / physiology*
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Glucocorticoids
  • Receptors, Glucocorticoid
  • Transcription Factors
  • Tumor Suppressor Protein p53