Metallopanstimulin is overexpressed in a patient with colonic carcinoma

Anticancer Res. May-Jun 1997;17(3C):1993-9.

Abstract

Background: Human metallopanstimulin (MPS-1) is a 9.4-kDa multifunctional ribosomal S27 nuclear "zinc finger" protein which is expressed in a wide variety of actively proliferating cells and tumor tissues. In this paper, we present a case of overexpression of MPS-1 in colon cancer tissues of a seventeen year old male.

Methods: Biopsies at the anastomosis and adjacent normal colonic mucosa were obtained by colonoscopy twelve months after right hemicolectomy for an ascending colon well differentiated adenocarcinoma. Immunohistochemical localization of MPS-1 protein was performed by using specific anti-MPS-1 antibodies directed against the N-terminal region of this protein.

Results: Immunohistochemistry demostrated an overexpression of MPS-1 in colonic mucosa crypts in the samples obtained at the anastomosis. In contrast, no expression of MPS-1 was observed in the adjacent normal mucosa. Histopathology performed with hematoxilin and eosin staining revealed focal crypt distortion and proliferation, but no carcinoma.

Conclusions: In this case, the overexpression of MPS-1 was a more definitive evidence of malignant transformation than histology, as demonstrated by the clinical course of the disease. The results support the hypothesis that increased levels of tissue MPS-1 may correlate with a more aggressive behavior of colon malignancy.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Adolescent
  • Amino Acid Sequence
  • Biopsy
  • Colectomy
  • Colonic Neoplasms / metabolism*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery
  • Colonoscopy
  • Humans
  • Immunohistochemistry
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / pathology
  • Male
  • Metalloproteins / analysis
  • Metalloproteins / biosynthesis*
  • Metalloproteins / chemistry
  • Molecular Sequence Data
  • Nuclear Proteins / analysis
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / chemistry
  • Peptide Fragments / chemistry
  • Peptide Fragments / immunology
  • RNA-Binding Proteins
  • Ribosomal Proteins*
  • Zinc Fingers

Substances

  • Metalloproteins
  • Nuclear Proteins
  • Peptide Fragments
  • RNA-Binding Proteins
  • RPS27 protein, human
  • Ribosomal Proteins