Prevalence of anti-FVIII antibodies in severe haemophilia A patients with inversion of intron 22

Br J Haematol. 1997 Jun;97(4):807-9. doi: 10.1046/j.1365-2141.1997.1082922.x.


The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inhibitory anti-FVIII antibodies in patients with factor VIII gene inversion has been extensively evaluated, but if this defect has to be considered a predisposing factor is still debatable. Non-inhibitory anti-FVIII antibodies are attracting interest, due to the potential influence on FVIII half-life. Our data show that FVIII gene inversion was a major predisposing factor for anti-FVIII antibodies development.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies / analysis*
  • Antibodies / genetics
  • Chromosome Inversion*
  • Enzyme-Linked Immunosorbent Assay
  • Factor VIII / genetics
  • Factor VIII / immunology*
  • Hemophilia A / genetics
  • Hemophilia A / immunology*
  • Humans
  • Introns / immunology*
  • Middle Aged
  • Risk Factors


  • Antibodies
  • Factor VIII