Primary progressive multiple sclerosis

Brain. 1997 Jun:120 ( Pt 6):1085-96. doi: 10.1093/brain/120.6.1085.


Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease.

Publication types

  • Review

MeSH terms

  • Disease Progression
  • Humans
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / genetics
  • Multiple Sclerosis / physiopathology*
  • Recurrence