Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness

Acta Physiol Hung. 1996;84(3):275-6.


In electrically driven myocardial preparations obtained from chronically methylxanthine-[aminophylline (APH) and 8-phenyltheophylline (8-PT)] or solvent(DMSO)-treated guinea pigs no differences were found in alteration of mechanical activity under hypoxia and reoxygenation. The vasoconstrictor effects observed after in vitro exposure of pulmonary arterial preparations (excised from either methylxanthine- or solvent-treated guinea pigs) to both noradrenaline and PGF2 alpha were also similar. In methylxanthine-treated vascular tissues, however, nitroglycerin and NO exerted more pronounced vasorelaxant effect than in specimens prepared from solvent-treated guinea pigs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminophylline / pharmacology
  • Animals
  • Atrial Function / drug effects
  • Cardiotonic Agents / pharmacology
  • Dinoprost / pharmacology
  • Female
  • Guinea Pigs
  • Hypoxia / physiopathology*
  • In Vitro Techniques
  • Muscle, Smooth, Vascular / drug effects*
  • Nitric Oxide / pharmacology
  • Norepinephrine / pharmacology
  • Pulmonary Artery / drug effects
  • Pulmonary Artery / physiopathology
  • Purinergic P1 Receptor Antagonists*
  • Theophylline / analogs & derivatives
  • Theophylline / pharmacology
  • Time Factors
  • Vasoconstriction


  • Cardiotonic Agents
  • Purinergic P1 Receptor Antagonists
  • Aminophylline
  • Nitric Oxide
  • Dinoprost
  • Theophylline
  • 8-phenyltheophylline
  • Norepinephrine