Balo's concentric sclerosis: a clinical case study of brain MRI, biopsy, and proton magnetic resonance spectroscopic findings

J Neurol Neurosurg Psychiatry. 1997 Jun;62(6):655-8. doi: 10.1136/jnnp.62.6.655.


The antemortem diagnosis of Balo's concentric sclerosis was made in a 52 year old woman with subacute right hemiparesis on the basis of brain MRI and stereotactic brain biopsy, which showed multiple ring-like lesions of lamellated demyelination alternating with spared white matter. Proton magnetic resonance spectroscopy (1H-MRS) was carried out one and nine months after the onset of illness. The first 1H-MRS showed a decreased N-acetyl aspartate peak, an increased choline peak, presence of large lipid peaks, and high resonance at 1.4 ppm. The second 1H-MRS disclosed changes such as a decrease of lipid signal, a decrease of resonance at 1.4 ppm, and an increase in the myoinositol peak. These findings are similar to those reported for multiple sclerosis. It seems that this is the first report of 1H-MRS findings in Balo's concentric sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Biopsy, Needle*
  • Diffuse Cerebral Sclerosis of Schilder / pathology*
  • Evoked Potentials, Auditory, Brain Stem
  • Fatal Outcome
  • Female
  • Frontal Lobe / pathology*
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy*
  • Middle Aged
  • Stereotaxic Techniques