The Bacillus subtilis DivIVA protein targets to the division septum and controls the site specificity of cell division

Mol Microbiol. 1997 Jun;24(5):905-15. doi: 10.1046/j.1365-2958.1997.3811764.x.

Abstract

The Bacillus subtilis divIVA gene, first defined by a mutation giving rise to anucleate minicells, has been cloned and characterized. Depletion of DivIVA leads to inhibition of the initiation of cell division. The residual divisions that do occur are abnormally placed and sometimes misorientated relative to the long axis of the cell. The DivIVA phenotype can be suppressed by disruption of the MinCD division inhibitor, suggesting that DivIVA controls the topological specificity of MinCD action and thus septum positioning. A DivIVA-GFP fusion targets to new and used sites of cell division, consistent with it having a direct role in topological specification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Amino Acid Sequence
  • Bacillus subtilis / genetics
  • Bacillus subtilis / physiology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology*
  • Base Sequence
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / physiology*
  • Cell Division / genetics
  • Cell Division / physiology
  • DNA, Bacterial
  • Escherichia coli Proteins*
  • Genes, Bacterial
  • Molecular Sequence Data
  • Mutagenesis
  • Recombinant Fusion Proteins / genetics
  • Repressor Proteins / genetics

Substances

  • Bacterial Proteins
  • Cell Cycle Proteins
  • DNA, Bacterial
  • DivIVA protein, bacteria
  • Escherichia coli Proteins
  • Recombinant Fusion Proteins
  • Repressor Proteins
  • Adenosine Triphosphatases
  • MinD protein, E coli

Associated data

  • GENBANK/Z86114