Porcine gastric mucosa associated lymphoid tissue (MALT): stimulation by colonization with the gastric bacterial pathogen, Helicobacter pylori

Vet Immunol Immunopathol. 1997 May;56(1-2):119-31. doi: 10.1016/s0165-2427(96)05736-4.

Abstract

The presence and features of mucosa associated lymhoid tissue (MALT), analogous to Peyer's patches, in the cardia of the lesser curvature of the porcine stomach are described. The gastric mucosa associated lymphoid tissue (gastric-MALT) is histologically distinct from gastric inflammation associated with colonization by normal gastric microflora and experimental bacterial colonization with a human gastric bacterial pathogen, Helicobacter pylori. The gastric-MALT consists of well-demarcated encapsulated and organized lymphoid tissue, intimately associated with overlying gastric epithelium, centered below the muscularis mucosae and drained by efferent lymphatics. Gastric-MALT was identified in all piglets studied including microbially sterile uninfected gnotobiotes; these structures were enlarged with age and local (gastric) antigenic stimulation. Significant (P < 0.05) expansion of the gastric-MALT occurred in H. pylori-infected gnotobiotic piglets. These distinct morphologic features and location in the cardia suggest that lymphoid elements in the gastric-MALT are involved in gastric antigen processing and regional lymphoid maturation, differentiation and proliferation in the stomach.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Gastric Mucosa / immunology*
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Germ-Free Life
  • Helicobacter Infections / immunology*
  • Helicobacter Infections / pathology
  • Helicobacter Infections / veterinary*
  • Helicobacter pylori / growth & development*
  • Helicobacter pylori / immunology*
  • Humans
  • Lymphocyte Activation*
  • Lymphoid Tissue / immunology*
  • Lymphoid Tissue / microbiology
  • Lymphoid Tissue / pathology
  • Organ Specificity / immunology
  • Swine
  • Swine Diseases / immunology*
  • Swine Diseases / microbiology
  • Swine Diseases / pathology