Pharmacotherapy for opioid and cocaine abuse

Med Clin North Am. 1997 Jul;81(4):909-25. doi: 10.1016/s0025-7125(05)70555-1.


The need for continued development of medications to address opioid and cocaine addiction is unequivocal. Methadone maintenance, despite its limitations, remains the best-established pharmacologic treatment for opioid dependence. Continued participation in methadone programs is associated with decreased risk of acquiring HIV infection. Clonidine alone or combined with naltrexone may be used for opioid detoxification in the office practice. At the present time, no proven pharmacologic therapy for cocaine addiction exists.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / therapeutic use
  • Cocaine*
  • Dopamine Agonists / therapeutic use
  • Female
  • Humans
  • Methadone / therapeutic use
  • Narcotic Antagonists / therapeutic use
  • Narcotics* / agonists
  • Narcotics* / therapeutic use
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Substance-Related Disorders / drug therapy*


  • Antidepressive Agents
  • Dopamine Agonists
  • Narcotic Antagonists
  • Narcotics
  • Cocaine
  • Methadone