The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases

FEBS Lett. 1997 Jun 16;409(3):325-32. doi: 10.1016/s0014-5793(97)00446-8.


A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families. Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members). It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / genetics
  • Amino Acid Sequence
  • Genome, Fungal
  • Molecular Sequence Data
  • Phylogeny
  • Saccharomyces cerevisiae / chemistry*
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae / genetics


  • Adenosine Triphosphatases