Expression of trypsin in vascular endothelial cells

FEBS Lett. 1997 Jun 16;409(3):442-8. doi: 10.1016/s0014-5793(97)00565-6.


Proteinases produced by vascular endothelial cells are expected to play important roles in many biological processes. Here we report that human vascular endothelial cells express trypsinogen-2 mRNA and its protein product in culture. The trypsinogen production was stimulated by a tumor promoter and associated with cell growth. In situ hybridization analysis showed that the trypsinogen gene was significantly expressed in vascular endothelial cells around gastric tumors and in patients with disseminated intravascular coagulation (DIC). These results suggest the possible roles of endothelial cell-derived trypsin in tumor angiogenesis and abnormal blood coagulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / enzymology*
  • Humans
  • In Situ Hybridization
  • Microcirculation / cytology
  • Microcirculation / enzymology
  • Skin / blood supply*
  • Skin / cytology
  • Skin / enzymology*
  • Trypsin / biosynthesis*
  • Trypsinogen / biosynthesis
  • Umbilical Veins


  • Trypsinogen
  • Trypsin