The invasion-associated type-III protein secretion system in Salmonella--a review

Gene. 1997 Jun 11;192(1):51-9. doi: 10.1016/s0378-1119(96)00825-6.


The genetic determinants that confer upon Salmonella the ability to enter non-phagocytic cells are largely encoded in a pathogenicity island located at centisome 63 of the bacterial chromosome. Molecular genetic analysis has revealed that this region encodes a specialized protein secretion system that mediates the export and/or translocation of putative signaling proteins into the host cell. This protein secretion system, which has been termed type III or contact-dependent, has also been identified in other plant and animal pathogens that have, in common, the ability to interact with eukaryotic host cells in an intimate manner.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Bacterial
  • Membrane Transport Proteins*
  • Proton-Translocating ATPases / metabolism
  • Salmonella / genetics
  • Salmonella / metabolism
  • Salmonella / pathogenicity*
  • Shigella / chemistry
  • Shigella / metabolism
  • Transcription, Genetic


  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Membrane Transport Proteins
  • PrgH protein, Salmonella typhimurium
  • invC protein, Salmonella typhimurium
  • invG protein, Salmonella typhimurium
  • Proton-Translocating ATPases