5-HT receptor classification and nomenclature: towards a harmonization with the human genome

Neuropharmacology. Apr-May 1997;36(4-5):419-28. doi: 10.1016/s0028-3908(97)00036-1.


Molecular biology has dramatically advanced our knowledge and understanding of receptors for 5-hydroxytryptamine (5-HT). The existence of multiple 5-HT receptors defined using traditional pharmacological and biochemical approaches has now been amply confirmed, but gene products encoding putative "new" 5-HT receptors have also been discovered. In some cases, the absence of suitably selective agonists and antagonists has hampered determination of a physiological role for these gene products. This makes their classification as formally recognised receptors premature.

Publication types

  • Review

MeSH terms

  • Animals
  • Genome, Human*
  • Humans
  • Receptors, Serotonin / classification*
  • Receptors, Serotonin / genetics*
  • Terminology as Topic*


  • Receptors, Serotonin