Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

Psychiatry Clin Neurosci. 1997 Jun;51(3):135-8. doi: 10.1111/j.1440-1819.1997.tb02375.x.


It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar beta-amyloid protein. Reactive microglia and inflammatory factors were reported to be present in beta-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1 immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

MeSH terms

  • Aged
  • Alzheimer Disease / immunology*
  • Alzheimer Disease / physiopathology
  • Brain Chemistry
  • Chemokine CCL2 / isolation & purification*
  • Humans
  • Immunohistochemistry
  • Inflammation
  • Microglia / immunology*
  • Middle Aged
  • Neurofibrillary Tangles / immunology*


  • Chemokine CCL2