Gestational diabetes and preterm labour: is glycaemic control a contributing factor?

Eur J Obstet Gynecol Reprod Biol. 1997 Jun;73(2):111-4. doi: 10.1016/s0301-2115(97)02707-3.

Abstract

Objectives: (1) to evaluate the incidence of preterm delivery in patients with gestational diabetes mellitus; (2) to determine the association between glycaemic control and preterm delivery in these patients.

Study design: (1) The incidence of spontaneous preterm singleton deliveries was determined in 550 intensively-treated patients with gestational diabetes mellitus. A total of 14 552 consecutive patients without gestational diabetes mellitus who delivered during the same interval served as a control population; (2) Glycaemic profiles (i.e., mean blood glucose, percent of hypoglycaemic [ < 60 mg/dl] and hyperglycaemic [ > 120 mg/dl] episodes) were compared in 34 patients with gestational diabetes mellitus who delivered preterm, and 68 matched controls with gestational diabetes mellitus who delivered at term.

Results: (1) The incidence of preterm delivery in gestational diabetics was similar to that found in the non-diabetic population (6.2% vs. 6.5%, respectively, P = 0.82; confidence limits: 0.65, 1.36); (2) women with gestational diabetes mellitus who delivered at term, or preterm had similar glycaemic profiles for both the entire treatment period and the week preceding delivery.

Conclusions: (1) There is no increased risk for preterm delivery in intensively-treated gestational diabetes mellitus patients; (2) In a population such as this women with gestational diabetes mellitus who deliver preterm cannot be characterised by their glycaemic profile.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Databases, Factual
  • Diabetes, Gestational / blood*
  • Female
  • Humans
  • Incidence
  • Obstetric Labor, Premature / blood*
  • Obstetric Labor, Premature / epidemiology
  • Pregnancy
  • Prospective Studies
  • Risk Factors

Substances

  • Blood Glucose