Abstract
A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / chemistry*
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Antibodies, Monoclonal / pharmacokinetics
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Astatine / pharmacokinetics*
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Glioma / diagnostic imaging*
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Half-Life
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Humans
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Injections, Intravenous
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Injections, Spinal
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Iodine Radioisotopes
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Mice
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Neoplasm Transplantation
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Radiation Dosage
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Radionuclide Imaging
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Radiopharmaceuticals / administration & dosage
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / pharmacokinetics
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Tissue Distribution
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Transplantation, Heterologous
Substances
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Antibodies, Monoclonal
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Iodine Radioisotopes
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Radiopharmaceuticals
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Astatine